Efficiency of Commercially Out there Serological Screening Assessments for Human T-Cell Lymphotropic Virus An infection in Brazil.
Serological screening for human T-cell lymphotropic virus sort 1 (HTLV-1) is often carried out utilizing enzyme-linked immunosorbent assay (ELISA), particle agglutination, or chemiluminescence assay kits. Attributable to an antigen matrix enchancment entailing the usage of new HTLV antigens and modifications within the format of HTLV screening assessments, in addition to newly launched chemiluminescence assays (CLIAs), a scientific analysis of the accuracy of at present out there business assessments is warranted.
We aimed to evaluate the efficiency of commercially out there screening assessments for HTLV an infection analysis. A diagnostic accuracy research was performed on a panel of 397 plasma samples: 200 HTLV-negative plasma samples, 170 HTLV-positive plasma samples, and 27 plasma samples indeterminate by Western blotting (WB).
WB-indeterminate samples (i.e., these yielding no particular bands for HTLV-1 and/or HTLV-2) have been assessed by PCR, and the outcomes have been used to check settlement among the many commercially out there ELISA screening assessments. For efficiency evaluation, WB-indeterminate samples have been excluded, leading to a last research panel of 370 samples. Three ELISA kits (Murex HTLV-1\/2 [Murex], anti-HTLV-1\/2 SYM Resolution [SYM Solution], and Gold ELISA HTLV-1\/2 [Gold ELISA]) and one CLIAequipment (Architect rHTLV-1\/2) have been evaluated.
All screening assessments demonstrated 100% sensitivity. Regarding the HTLV-negative samples, the SYM Resolution and Gold ELISA kits had specificity values of >99.5%, whereas the Architect rHTLV-1\/2 check offered 98.1% specificity, adopted by Murex, which had a specificity of 92.0%. Relating to the 27 samples with WB-indeterminate outcomes, after PCR affirmation, all ELISA kits confirmed 100% sensitivity however low specificity.
Accuracy findings have been corroborated by way of Cohen’s kappa worth, which evidenced slight and truthful settlement between PCR evaluation and ELISAs for HTLV an infection analysis. Based mostly on the information, we imagine that every one evaluated assessments could be safely used for HTLV an infection screening.
Description: Double-antibody Sandwich chemiluminescent immunoassay for detection of Human Myoglobin (MYO)Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Myoglobin (MYO) in samples from serum, plasma, tissue homogenates or other biological fluids.
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Myoglobin (MYO) in samples from serum, plasma, tissue homogenates or other biological fluids.
Description: A sandwich quantitative ELISA assay kit for detection of Porcine Myoglobin (MYO) in samples from serum, plasma, tissue homogenates or other biological fluids.
Description: A sandwich quantitative ELISA assay kit for detection of Porcine Myoglobin (MYO) in samples from serum, plasma, tissue homogenates or other biological fluids.
Description: A sandwich quantitative ELISA assay kit for detection of Rat Myoglobin (MYO) in samples from serum, plasma, tissue homogenates or other biological fluids.
Description: A sandwich quantitative ELISA assay kit for detection of Rat Myoglobin (MYO) in samples from serum, plasma, tissue homogenates or other biological fluids.
Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Mouse Myoglobin (MYO) in serum, plasma, tissue homogenates and other biological fluids.
Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Mouse Myoglobin (MYO) in serum, plasma, tissue homogenates and other biological fluids.
Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Mouse Myoglobin (MYO) in serum, plasma, tissue homogenates and other biological fluids.
Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Mouse Myoglobin (MYO) in serum, plasma, tissue homogenates and other biological fluids.
Description: Double-antibody Sandwich chemiluminescent immunoassay for detection of Mouse Myoglobin (MYO)Serum, plasma, tissue homogenates and other biological fluids
Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Pig Myoglobin (MYO) in serum, plasma, tissue homogenates and other biological fluids.
Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Pig Myoglobin (MYO) in serum, plasma, tissue homogenates and other biological fluids.
Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Pig Myoglobin (MYO) in serum, plasma, tissue homogenates and other biological fluids.
Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Pig Myoglobin (MYO) in serum, plasma, tissue homogenates and other biological fluids.
Description: Double-antibody Sandwich chemiluminescent immunoassay for detection of Pig Myoglobin (MYO)Serum, plasma, tissue homogenates and other biological fluids
Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Rat Myoglobin (MYO) in serum, plasma, tissue homogenates and other biological fluids.
Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Rat Myoglobin (MYO) in serum, plasma, tissue homogenates and other biological fluids.
Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Rat Myoglobin (MYO) in serum, plasma, tissue homogenates and other biological fluids.
Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Rat Myoglobin (MYO) in serum, plasma, tissue homogenates and other biological fluids.
Description: Double-antibody Sandwich chemiluminescent immunoassay for detection of Rat Myoglobin (MYO)Serum, plasma, tissue homogenates and other biological fluids
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Myoglobin (MYO) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Myoglobin (MYO) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Myoglobin (MYO) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Myoglobin (MYO) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Myoglobin (MYO) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids with no significant corss-reactivity with analogues from other species.
Description: Quantitativesandwich ELISA kit for measuring Human Myoglobin, MYO/MB in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.
Description: Quantitativesandwich ELISA kit for measuring Human Myoglobin, MYO/MB in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.
Description: A sandwich ELISA kit for detection of Myoglobin from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids.
Description: A sandwich ELISA kit for detection of Myoglobin from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids.
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Myoglobin (MYO) in serum, plasma, tissue homogenates and other biological fluids.
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Myoglobin (MYO) in serum, plasma, tissue homogenates and other biological fluids.
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Myoglobin (MYO) in serum, plasma, tissue homogenates and other biological fluids.
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Myoglobin (MYO) in serum, plasma, tissue homogenates and other biological fluids.
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Mouse Myoglobin (MYO) in samples from serum, plasma, tissue homogenates and other biological fluids with no significant corss-reactivity with analogues from other species.
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Pig Myoglobin (MYO) in serum, plasma, tissue homogenates and other biological fluids.
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Pig Myoglobin (MYO) in serum, plasma, tissue homogenates and other biological fluids.
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Pig Myoglobin (MYO) in serum, plasma, tissue homogenates and other biological fluids.
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Pig Myoglobin (MYO) in serum, plasma, tissue homogenates and other biological fluids.
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Pig Myoglobin (MYO) in samples from Serum, plasma, tissue homogenates and other biological fluids with no significant corss-reactivity with analogues from other species.
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Rat Myoglobin (MYO) in serum, plasma, tissue homogenates and other biological fluids.
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Rat Myoglobin (MYO) in serum, plasma, tissue homogenates and other biological fluids.
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Rat Myoglobin (MYO) in serum, plasma, tissue homogenates and other biological fluids.
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Rat Myoglobin (MYO) in serum, plasma, tissue homogenates and other biological fluids.
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Rat Myoglobin (MYO) in samples from serum, plasma, tissue homogenates and other biological fluids with no significant corss-reactivity with analogues from other species.
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Rabbit Myoglobin (MYO) in serum, plasma and other biological fluids.
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Rabbit Myoglobin (MYO) in serum, plasma and other biological fluids.
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Rabbit Myoglobin (MYO) in serum, plasma and other biological fluids.
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Rabbit Myoglobin (MYO) in serum, plasma and other biological fluids.
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Rabbit Myoglobin (MYO) in samples from Serum, plasma and other biological fluids. with no significant corss-reactivity with analogues from other species.
Improvement of a Time-Resolved Fluorescence Immunoassay for the Prognosis of Hepatocellular Carcinoma Based mostly on the Detection of Glypican-3.
Glypican-3(GPC3), an oncofetal protein, is a possible novel marker for hepatocellular carcinoma (HCC). On this research, we tried to determine a brand new technique to detect serum GPC3 utilizing the antibodies recognized in our earlier analysis, after which evaluated its scientific utility for the analysis of HCC.
Herein, a sandwich time-resolved fluorescence immunoassay (TRFIA) for detecting serum GPC3 was developed. The detection restrict, analytical restoration, specificity and precision of the proposed TRFIA assay have been passable. A complete of 415 sufferers have been collected and divided into seven teams: hepatocellular carcinoma (101), colorectal most cancers (67), gastric most cancers (44), esophageal most cancers (15), cirrhosis (55), hepatitis (61), regular liver (72).
Utilizing this proposed technique, the focus of serum GPC3 in these scientific samples was detected. The outcomes demonstrated that the ranges of GPC3 in serum from HCC sufferers have been considerably larger than that in others. In contrast with the outcomes of chemiluminescence immunoassay (CLIA), a excessive consistency (Kappa =0.84) was noticed.
Thus, an efficient, delicate and dependable TRFIA-GPC3 equipment for diagnosing HCC was efficiently developed. It gives an appropriate different to existed strategies of figuring out GPC3 and is predicted for use in clinic sooner or later.
Chemiluminescence Immunoassay for the Detection of Antibodies in opposition to the 2C and 3ABC Nonstructural Proteins Induced by Infecting Pigs with Foot-and-Mouth Illness Virus.
The potential diagnostic worth of chemiluminescence immunoassays (CLIAs) has been accepted lately, though their use for foot-and-mouth illness (FMD) diagnostics has not been reported.
Full-length 3ABC and 2C proteins have been expressed in micro organism and purified by affinity chromatography to develop a fast and correct strategy to differentiate pigs contaminated with foot-and-mouth illness virus (FMDV) from vaccinated pigs.The recombinant proteins have been then used as antigens to develop two CLIAsfor the detection of antibodies in opposition to nonstructural viral proteins.
The diagnostic efficiency of the 2 assays was in contrast by analyzing serum from pigs (naive pigs, n = 63; vaccinated, uninfected pigs, n = 532; naive, contaminated pigs, n = 117) with a recognized an infection standing. The 3ABC-2C CLIAhad the next accuracy fee, with a diagnostic sensitivity of 100% and a diagnostic specificity of 96.5%, than the 3ABC CLIA, which had a diagnostic sensitivity of 95.7% and a diagnostic specificity of 96.0%.
The outcomes of the 3ABC-2C CLIAadditionally had a excessive fee of concordance with these of two business FMDV enzyme-linked immunosorbent assay (ELISA) kits used to evaluate serum collected from 962 pigs within the discipline (96.2% and 97.8%, respectively). The 3ABC-2C CLIA detected an infection in serum samples from contaminated pigs sooner than the business ELISA kits.
As well as, the 3ABC-2C CLIAproduced outcomes inside 15 min. On the idea of those findings, the 3ABC-2C CLIA might function the inspiration for the event of penside FMD diagnostics and gives an alternate technique to detect FMDV infections.
Description: Sandwich ELISA kit used for quantitate HSP70 concentration in Serum, Plasma, Cell Lysates, Tissue samples from Human, Monkey, Dog, Rat, Mouse
Description: A sandwich CLIA kit for quantitative measurement of Human hs-CRP (high-sensitivity C-reactive protein) in samples from Serum, Plasma, Cell supernatant
CLIA kit for Mouse hs-CRP (high sensitivity C-Reactive Protein)
Description: A sandwich CLIA kit for quantitative measurement of Mouse hs-CRP (high sensitivity C-Reactive Protein) in samples from Serum, Plasma, Cell supernatant
CLIA kit for Rat hs-CRP (High Sensitivity C-Reactive Protein)
Description: A sandwich CLIA kit for quantitative measurement of Rat hs-CRP (High Sensitivity C-Reactive Protein) in samples from Serum, Plasma, Cell supernatant
Description: Thishigh-sensitivity Human Growth Hormone ELISA Kit is to be used for the invitro quantitative determination of human growth hormone (hGH) concentrationsin serum.
High Sensitivity Polyethylene Glycol (PEG) ELISA Kit
Description: Cell Biolabs? High Sensitivity Protein Quantitation Assay Kit utilizes a fluorogenic detection dye to measure primary aliphatic amines (peptides or proteins) in various samples with much greater sensitivity than the conventional colorimetric protein determination methods. The assay is performed in a 96-well microtiter plate format and measured within 15 minutes. Each kit provides sufficient reagents to perform up to 200 assays, including blanks, standards and unknown samples. The kit contains a BSA standard and has a detection sensitivity limit of < 5 ug/mL.
Description: Description of target: The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca2+-dependent exocytosis of IGF1 is required for sensory perception of smell in the olfactory bulb. Acts as a ligand for IGF1R. Binds to the alpha subunit of IGF1R, leading to the activation of the intrinsic tyrosine kinase activity which autophosphorylates tyrosine residues in the beta subunit thus initiatiating a cascade of down-stream signaling events leading to activation of the PI3K-AKT/PKB and the Ras-MAPK pathways. Binds to integrins ITGAV:ITGB3 and ITGA6:ITGB4. Its binding to integrins and subsequent ternary complex formation with integrins and IGFR1 are essential for IGF1 signaling. Induces the phosphorylation and activation of IGFR1, MAPK3/ERK1, MAPK1/ERK2 and AKT1.;Species reactivity: Dog;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 6.5 pg/mL
Il10 High Sensitivity ELISA Kit (Mouse) (OKCD01301)
Description: Description of target: Inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T-cells. ;Species reactivity: Mouse;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 0.43 pg/mL
Il1a High Sensitivity ELISA Kit (Mouse) (OKCD01303)
Description: Description of target: Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells. ;Species reactivity: Mouse;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 1.03 pg/mL
Description: Description of target: Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells. ;Species reactivity: Rat;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 3.8 pg/mL
IL2 High Sensitivity ELISA Kit (Human) (OKCD01305)
Description: Description of target: Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells. ;Species reactivity: Human;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 0.51 pg/mL
IL6 High Sensitivity ELISA Kit (Bovine) (OKCD01306)
Description: Description of target: Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation.;Species reactivity: Bovine;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 0.45 pg/mL
Description: Description of target: Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation.;Species reactivity: Goat;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 0.138 pg/mL
IL6 High Sensitivity ELISA Kit (Human) (OKCD01308)
Description: Description of target: Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation. ;Species reactivity: Human;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 0.35 pg/mL
IL6 High Sensitivity ELISA Kit (Sheep) (OKCD01309)
Description: Description of target: Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation.;Species reactivity: Sheep;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 0.46 pg/mL
Description: Description of target: Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation.;Species reactivity: Rat;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 0.47 pg/mL
IL8 High Sensitivity ELISA Kit (Human) (OKCD01311)
Description: Description of target: IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus. IL-8(6-77) has a 5-10-fold higher activity on neutrophil activation, IL-8(5-77) has increased activity on neutrophil activation and IL-8(7-77) has a higher affinity to receptors CXCR1 and CXCR2 as compared to IL-8(1-77), respectively.;Species reactivity: Human;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 1.7 pg/mL
Description: Description of target: Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X. ;Species reactivity: Rabbit;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 11.5 pg/mL
MMP13 High Sensitivity ELISA Kit (Human) (OKCD01314)
Description: Description of target: Plays a role in the degradation of extracellular matrix proteins including fibrillar collagen, fibronectin, TNC and ACAN. Cleaves triple helical collagens, including type I, type II and type III collagen, but has the highest activity with soluble type II collagen. Can also degrade collagen type IV, type XIV and type X. May also function by activating or degrading key regulatory proteins, such as TGFB1 and CTGF. Plays a role in wound healing, tissue remodeling, cartilage degradation, bone development, bone mineralization and ossification. Required for normal embryonic bone development and ossification. Plays a role in the healing of bone fractures via endochondral ossification. Plays a role in wound healing, probably by a mechanism that involves proteolytic activation of TGFB1 and degradation of CTGF. Plays a role in keratinocyte migration during wound healing. May play a role in cell migration and in tumor cell invasion.1;Species reactivity: Human;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 12.1 pg/mL
Mmp13 High Sensitivity ELISA Kit (Mouse) (OKCD01315)
Description: Description of target: Plays a role in the degradation of extracellular matrix proteins including fibrillar collagen, fibronectin, TNC and ACAN. Cleaves triple helical collagens, including type I, type II and type III collagen, but has the highest activity with soluble type II collagen. Can also degrade collagen type IV, type XIV and type X. May also function by activating or degrading key regulatory proteins, such as TGFB1 and CTGF. Plays a role in wound healing, tissue remodeling, cartilage degradation, bone development, bone mineralization and ossification. Required for normal embryonic bone development and ossification. Plays a role in the healing of bone fractures via endochondral ossification. Plays a role in wound healing, probably by a mechanism that involves proteolytic activation of TGFB1 and degradation of CTGF. Plays a role in keratinocyte migration during wound healing. May play a role in cell migration and in tumor cell invasion.;Species reactivity: Mouse;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: < 6.3 pg/mL
NGF High Sensitivity ELISA Kit (Human) (OKCD01316)
Description: Description of target: Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades through those receptor tyrosine kinase to regulate neuronal proliferation, differentiation and survival. Inhibits metalloproteinase dependent proteolysis of platelet glycoprotein VI.;Species reactivity: Human;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 0.97 pg/mL
Cxcl12 High Sensitivity ELISA Kit (Rat) (OKCD01317)
Description: Description of target: Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation. Impairs regulatory T-cells (Treg) function in individuals with rheumatoid arthritis via FOXP3 dephosphorylation. Upregulates the expression of protein phosphatase 1 (PP1), which dephosphorylates the key 'Ser-418' residue of FOXP3, thereby inactivating FOXP3 and rendering Treg cells functionally defective. Key mediator of cell death in the anticancer action of BCG-stimulated neutrophils in combination with DIABLO/SMAC mimetic in the RT4v6 bladder cancer cell line.;Species reactivity: Rat;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 5.5 pg/mL
TNF High Sensitivity ELISA Kit (Human) (OKCD01318)
Description: Description of target: Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation. Impairs regulatory T-cells (Treg) function in individuals with rheumatoid arthritis via FOXP3 dephosphorylation. Upregulates the expression of protein phosphatase 1 (PP1), which dephosphorylates the key 'Ser-418' residue of FOXP3, thereby inactivating FOXP3 and rendering Treg cells functionally defective. Key mediator of cell death in the anticancer action of BCG-stimulated neutrophils in combination with DIABLO/SMAC mimetic in the RT4v6 bladder cancer cell line.;Species reactivity: Human;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 0.49 pg/mL
IFNB High Sensitivity ELISA Kit (Chicken) (OKCD01319)
Description: Description of target: Inhibits factor X (X(a)) directly and, in a Xa-dependent way, inhibits VIIa/tissue factor activity, presumably by forming a quaternary Xa/LACI/VIIa/TF complex. It possesses an antithrombotic action and also the ability to associate with lipoproteins in plasma. ;Species reactivity: Human;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 0.057 ng/mL
MBP High Sensitivity ELISA Kit (Human) (OKCD01323)
Description: Description of target: The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non-classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T-cells and neural cells. Differential splicing events combined with optional post-translational modifications give a wide spectrum of isomers, with each of them potentially having a specialized function. Induces T-cell proliferation.;Species reactivity: Human;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 6.4 pg/mL
IgG High Sensitivity ELISA Kit (Bovine) (OKCD01324)
Description: Description of target: Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage.;Species reactivity: Rat;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 5.3 pg/mL
Description: Description of target: Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing.;Species reactivity: Human;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 0.08 pg/mL
Description: Description of target: Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization.;Species reactivity: Human;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 5.4 pg/mL
Adam10 High Sensitivity ELISA Kit (Mouse) (OKCD01334)
Description: Description of target: Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth-like factor, ephrin-A2, CD44, CDH2 and for constitutive and regulated alpha-secretase cleavage of amyloid precursor protein (APP) at '687-Lys-|-Leu-688'. Contributes to the normal cleavage of the cellular prion protein. Involved in the cleavage of the adhesion molecule L1 at the cell surface and in released membrane vesicles, suggesting a vesicle-based protease activity. Controls also the proteolytic processing of Notch and mediates lateral inhibition during neurogenesis. Responsible for the FasL ectodomain shedding and for the generation of the remnant ADAM10-processed FasL (FasL APL) transmembrane form. Also cleaves the ectodomain of the integral membrane proteins CORIN and ITM2B. May regulate the EFNA5-EPHA3 signaling.;Species reactivity: Mouse;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 3.7 pg/mL
ORM1 High Sensitivity ELISA Kit (Human) (OKCD01335)
Description: Description of target: Functions as transport protein in the blood stream. Binds various ligands in the interior of its beta-barrel domain. Also binds synthetic drugs and influences their distribution and availability in the body. Appears to function in modulating the activity of the immune system during the acute-phase reaction.;Species reactivity: Human;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 0.41 ng/mL
Description: Description of target: As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an Antimicrobial; Antioxidant, has antibacterial activity and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidely cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway.;Species reactivity: Human;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 0.102 ng/mL
CRP High Sensitivity ELISA Kit (Bovine) (OKCD01337)
Description: Description of target: Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells. ;Species reactivity: Human;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 23.3 pg/mL
Description: Description of target: Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells.;Species reactivity: Rat;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 5.1 pg/mL
Description: Description of target: Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca2+, Na+, K+, fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.;Species reactivity: Human;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 0.55 ng/mL
LDL High Sensitivity ELISA Kit (Human) (OKCD01347)
Description: Description of target: May be involved in the regulation of cell-cell interactions or in synatogenesis during the maturation of the nervous system.;Species reactivity: Human;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 3.0 pg/mL
LYZ High Sensitivity ELISA Kit (Human) (OKCD01349)
Description: Description of target: Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. ;Species reactivity: Human;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 4.3 pg/mL
CTSD High Sensitivity ELISA Kit (Human) (OKCD01351)
Description: Description of target: Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation. Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease.;Species reactivity: Human;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 15.27 pg/mL
Description: Description of target: Plays a role in the innate immune response. Binds to the lipid A moiety of bacterial lipopolysaccharides (LPS), a glycolipid present in the outer membrane of all Gram-negative bacteria. Acts as an affinity enhancer for CD14, facilitating its association with LPS. Promotes the release of cytokines in response to bacterial lipopolysaccharide.;Species reactivity: Rat;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 5.4 pg/mL
Description: Description of target: Involved in the maintenance and repair of the intestinal mucosa. Promotes the mobility of epithelial cells in healing processes (motogen).;Species reactivity: Rat;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 19.11 pg/mL
APOB48 High Sensitivity ELISA Kit (Human) (OKCD01355)
Description: Description of target: May have a role in chylomicrons and VLDL secretion and catabolism. Required for efficient activation of lipoprotein lipase by ApoC-II; potent activator of LCAT. Apoa-IV is a major component of HDL and chylomicrons.;Species reactivity: Mouse;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 2.7 pg/mL
MAPT High Sensitivity ELISA Kit (Human) (OKCD01360)
Description: Description of target: Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.;Species reactivity: Human;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 11.8 pg/mL
Mapt High Sensitivity ELISA Kit (Mouse) (OKCD01361)
Description: Description of target: Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. ;Species reactivity: Mouse;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 2.5 pg/mL
Description: Description of target: Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. ;Species reactivity: Rat;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 2.8 pg/mL
APOB High Sensitivity ELISA Kit (Human) (OKCD01363)
Description: Description of target: Apolipoprotein B is a major protein constituent of chylomicrons (apo B-48), LDL (apo B-100) and VLDL (apo B-100). Apo B-100 functions as a recognition signal for the cellular binding and internalization of LDL particles by the apoB/E receptor. ;Species reactivity: Human;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 0.65 ng/mL
ApoB High Sensitivity ELISA Kit (Mouse) (OKCD01364)
Description: Description of target: Apolipoprotein B is a major protein constituent of chylomicrons (apo B-48), LDL (apo B-100) and VLDL (apo B-100). Apo B-100 functions as a recognition signal for the cellular binding and internalization of LDL particles by the apoB/E receptor. ;Species reactivity: Mouse;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 1.95 ng/mL
S100A4 High Sensitivity ELISA Kit (Human) (OKCD01366)
Description: Description of target: Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN-stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type-selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium. Exerts an immunomodulatory effect by up-regulating MHC class I antigen expression.;Species reactivity: Human;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 0.55 pg/mL
TRF High Sensitivity ELISA Kit (Human) (OKCD01368)
Description: Description of target: Transferrins are iron binding transport proteins which can bind two Fe3+ ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation.;Species reactivity: Mouse;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 0.051 ng/mL
Gdf11 High Sensitivity ELISA Kit (Mouse) (OKCD01370)
Description: Description of target: Secreted signal that acts globally to specify positional identity along the anterior/posterior axis during development. Play critical roles in patterning both mesodermal and neural tissues and in establishing the skeletal pattern. ;Species reactivity: Mouse;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 2.62 pg/mL
NOG High Sensitivity ELISA Kit (Human) (OKCD01371)
Description: Description of target: Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. Essential for cartilage morphogenesis and joint formation. Inhibits chondrocyte differentiation through its interaction with GDF5 and, probably, GDF6.;Species reactivity: Human;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 0.059 ng/mL
APOM High Sensitivity ELISA Kit (Human) (OKCD01372)
Description: Description of target: Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP5 may be involved in determining the polarity of photoreceptor, and perhaps, other cells in the retina. ;Species reactivity: Human;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 0.51 ng/mL
APOL1 High Sensitivity ELISA Kit (Human) (OKCD01378)
Description: Description of target: May play a role in lipid exchange and transport throughout the body. May participate in reverse cholesterol transport from peripheral cells to the liver. ;Species reactivity: Human;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 0.112 ng/mL
Ctsg High Sensitivity ELISA Kit (Mouse) (OKCD01379)
Description: Description of target: This vimentin-specific protease may regulate the reorganization of vimentin filaments, occurring during cell differentiation, movement and mitosis. ;Species reactivity: Mouse;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 1.25 pg/mL
NEFL High Sensitivity ELISA Kit (Human) (OKCD01380)
Description: Description of target: Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and they functionally maintain the neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the light chain neurofilament protein. Mutations in this gene cause Charcot-Marie-Tooth disease types 1F (CMT1F) and 2E (CMT2E), disorders of the peripheral nervous system that are characterized by distinct neuropathies. A pseudogene has been identified on chromosome Y.;Species reactivity: Human;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: < 0.61 pg/mL
Nefl High Sensitivity ELISA Kit (Mouse) (OKCD01381)
Description: Description of target: Neurofilaments usually contain three intermediate filament proteins: L, M, and H which are involved in the maintenance of neuronal caliber. ;Species reactivity: Mouse;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 1.95 pg/mL
Sumo1 High Sensitivity ELISA Kit (Mouse) (OKCD01382)
Description: Description of target: Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Involved for instance in targeting RANGAP1 to the nuclear pore complex protein RANBP2. Covalently attached to the voltage-gated potassium channel KCNB1; this modulates the gating characteristics of KCNB1. Polymeric SUMO1 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins. May also regulate a network of genes involved in palate development. Covalently attached to ZFHX3.;Species reactivity: Mouse;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 27 pg/mL
UMOD High Sensitivity ELISA Kit (Human) (OKCD01383)
Description: Description of target: Uromodulin: Functions in biogenesis and organization of the apical membrane of epithelial cells of the thick ascending limb of Henle's loop (TALH), where it promotes formation of complex filamentous gel-like structure that may play a role in the water barrier permeability (Probable). May serve as a receptor for binding and endocytosis of cytokines (IL-1, IL-2) and TNF. Facilitates neutrophil migration across renal epithelia.Curated;Species reactivity: Human;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 6.3 pg/mL
Description: Description of target: May have weak glycosidase activity towards glucuronylated steroids. However, it lacks essential active site Glu residues at positions 239 and 872, suggesting it may be inactive as a glycosidase in vivo. May be involved in the regulation of calcium and phosphorus homeostasis by inhibiting the synthesis of active vitamin D. Essential factor for the specific interaction between FGF23 and FGFR1.;Species reactivity: Human;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 6.5 pg/mL
PARK7 High Sensitivity ELISA Kit (Human) (OKCD01385)
Description: Description of target: Protein deglycase that repairs methylglyoxal- and glyoxal-glycated amino acids and proteins, and releases repaired proteins and lactate or glycolate, respectively. Deglycates cysteines, arginines and lysines residues in proteins, and thus reactivates these proteins by reversing glycation by glyoxals. Acts on early glycation intermediates (hemithioacetals and aminocarbinols), preventing the formation of advanced glycation endproducts (AGE). Plays an important role in cell protection against oxidative stress and cell death acting as oxidative stress sensor and redox-sensitive chaperone and protease; functions probably related to its primary function. It is involved in neuroprotective mechanisms like the stabilization of NFE2L2 and PINK1 proteins, male fertility as a positive regulator of androgen signaling pathway as well as cell growth and transformation through, for instance, the modulation of NF-kappa-B signaling pathway. Its involvement in protein repair could also explain other unrelated functions. Eliminates hydrogen peroxide and protects cells against hydrogen peroxide-induced cell death. Required for correct mitochondrial morphology and function as well as for autophagy of dysfunctional mitochondria. Plays a role in regulating expression or stability of the mitochondrial uncoupling proteins SLC25A14 and SLC25A27 in dopaminergic neurons of the substantia nigra pars compacta and attenuates the oxidative stress induced by calcium entry into the neurons via L-type channels during pacemaking. Regulates astrocyte inflammatory responses, may modulate lipid rafts-dependent endocytosis in astrocytes and neuronal cells. Binds to a number of mRNAs containing multiple copies of GG or CC motifs and partially inhibits their translation but dissociates following oxidative stress. Metal-binding protein able to bind copper as well as toxic mercury ions, enhances the cell protection mechanism against induced metal toxicity.;Species reactivity: Human;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 26.3 pg/mL
Rspo1 High Sensitivity ELISA Kit (Mouse) (OKCD01387)
Description: Description of target: Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway. Has a essential roles in ovary determination.;Species reactivity: Mouse;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 5.6 pg/mL
ENHO High Sensitivity ELISA Kit (Human) (OKCD01388)
Description: Description of target: Involved in the regulation of glucose homeostasis and lipid metabolism.;Species reactivity: Human;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 4.2 pg/mL
WNT3A High Sensitivity ELISA Kit (Human) (OKCD01389)
Description: Description of target: Ligand for members of the frizzled family of seven transmembrane receptors. Wnt-3 and Wnt-3a play distinct roles in cell-cell signaling during morphogenesis of the developing neural tube. ;Species reactivity: Human;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 0.062 ng/mL
C4d High Sensitivity ELISA Kit (Human) (OKCD01390)
Description: Description of target: General inhibitor of pancreatic serine proteases: inhibits chymotrypsin, trypsin, elastases, factor X, kallikrein as well as a variety of other proteases. The strength of inhibition does not appear to be correlated with a particular protease specificity. ;Species reactivity: E.coli;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 0.134 ng/mL
Description: Description of target: The protein encoded by this gene is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. Mutations in this gene are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis.;Species reactivity: Human;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: < 0.98 pg/mL
AccuBlue High Sensitivity dsDNA Quantitation Solution
Description: A sandwich CLIA kit for quantitative measurement of Rat CREB1 (Cyclic AMP Response Element Binding Protein 1) in samples from Serum, Plasma, Cell supernatant
Fish high sensitivity C- Reactive Protein ELISA Kit
Description: A sandwich ELISA for quantitative measurement of Human High sensitivity Cardiac Troponin I in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Human High sensitivity Cardiac Troponin I ELISA kit
Description: A sandwich ELISA for quantitative measurement of Human High sensitivity Cardiac Troponin I in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Human High sensitivity Cardiac Troponin I ELISA kit
Description: A sandwich ELISA for quantitative measurement of Human High sensitivity Cardiac Troponin I in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Human High sensitivity C Reactive Protein ELISA kit
Description: A competitive ELISA for quantitative measurement of Human High sensitivity C Reactive Protein in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Human High sensitivity C Reactive Protein ELISA kit
Description: A competitive ELISA for quantitative measurement of Human High sensitivity C Reactive Protein in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
 CLIA Kit)
 ELISA Kit)
 ELISA Kit)
 ELISA Kit)
 ELISA Kit)
CLIA Kit)
 CLIA Kit)
CLIA Kit)
 CLIA Kit)
CLIA Kit)
 CLIA Kit)
)
)
)
)
 ELISA Kit)
)
 ELISA Kit)
)
)
)
)
 Antibody)
 Protein)
)
)
)
)
ELISA Kit)
)
)
 ELISA Kit)
)
)
ELISA Kit)
 ELISA Kit)
 ELISA Kit)
 ELISA Kit)
 ELISA Kit)
 ELISA Kit)
ELISA Kit)
 Antibody Pair)
 Protein)
 Protein)
 Protein)
 Protein)
 Protein)
 Protein)
 Antibody (FITC))
 Antibody (Biotin))
 Antibody (APC))
 Protein)
)
)
)
)
)
 CLIA Kit)
 CLIA Kit)
 CLIA Kit)
)
)
 CLIA Kit)
)
)
)
)
 ELISA Kit)
)
)
)
 ELISA Kit)
 (OKCD01300))
 (OKCD01301))
 (OKCD01303))
 (OKCD01304))
 (OKCD01305))
 (OKCD01306))
 (OKCD01307))
 (OKCD01308))
 (OKCD01309))
 (OKCD01310))
 (OKCD01311))
 (OKCD01312))
 (OKCD01313))
 (OKCD01314))
 (OKCD01315))
 (OKCD01316))
 (OKCD01317))
 (OKCD01318))
 (OKCD01319))
 (OKCD01321))
 (OKCD01323))
 (OKCD01324))
 (OKCD01326))
 (OKCD01327))
 (OKCD01328))
 (OKCD01329))
 (OKCD01330))
 (OKCD01331))
 (OKCD01332))
 (OKCD01334))
 (OKCD01335))
 (OKCD01336))
 (OKCD01337))
 (OKCD01338))
 (OKCD01339))
 (OKCD01340))
 (OKCD01341))
 (OKCD01343))
 (OKCD01346))
 (OKCD01347))
 (OKCD01348))
 (OKCD01349))
 (OKCD01351))
 (OKCD01352))
 (OKCD01354))
 (OKCD01355))
 (OKCD01356))
 (OKCD01357))
 (OKCD01360))
 (OKCD01361))
 (OKCD01362))
 (OKCD01363))
 (OKCD01364))
 (OKCD01366))
 (OKCD01367))
 (OKCD01368))
 (OKCD01369))
 (OKCD01370))
 (OKCD01371))
 (OKCD01372))
 (OKCD01375))
 (OKCD01378))
 (OKCD01379))
 (OKCD01380))
 (OKCD01381))
 (OKCD01382))
 (OKCD01383))
 (OKCD01384))
 (OKCD01385))
 (OKCD01387))
 (OKCD01388))
 (OKCD01389))
 (OKCD01390))
 (OKCD01391))
 (OKDB00042))
)
)
)
